![]() ![]() The assessment of extracellular fluid status may help in the management of DME. 0.768).Ĭonclusion: DME patients had elevated body fluid volume independent of kidney functions. In the binary logistic regression for DME risk, the area under the receiver operating characteristic curve (AUROC) increased significantly by adding ECW/TBW along with UACR and age (AUC: 0.826 vs. In multilinear regression, fluid overload was positively related to DME and UACR (DME vs. Results: ECW/TBW was significantly increased in DME patients (39.2 ± 0.9, %) compared to DM (38.1 ± 0.7, %, P = 0.003) and DR patients without DME (38.7 ± 0.9, %, P < 0.001). Urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and albumin was obtained using serum and urine laboratory data. ![]() Central subfield thickness (CST) and macular volume (MV) were obtained using optical coherence tomography (OCT). The fluid status of each participant was quantified with extracellular water-to-total body water ratio (ECW/TBW) using a body composition monitor. Thirty-five were DM patients without diabetic retinopathy (DR), 31 were DR patients without DME, and 66 were DME patients. Methods: One hundred and thirty-two eyes from 132 patients with diabetes mellitus (DM) were prospectively collected in this cross-sectional, observational study. Objective: To investigate body fluid status in diabetic macular edema (DME) patients and the extent to which it is affected by renal function. 8School of Medicine, South China University of Technology, Guangzhou, China.7Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.6Southern Medical University, Guangzhou, China.5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.4Department of Nephrology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.3Department of Nutrition, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China. ![]() 2Shantou University Medical College, Shantou, China.1Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.Jie Yao 1,2 † Qingsheng Peng 1 † Yuanhong Li 3 † Anyi Liang 1 Jianteng Xie 4 Xuenan Zhuang 1,5 Ruoyu Chen 1,6 Yesheng Chen 1,6,7 Zicheng Wang 1,8 Liang Zhang 1,2,6 * Dan Cao 1,6,7 * ![]()
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